By Li Di,Edward H. Kerns
Focused on relevant frightened method (CNS) drug discovery efforts, this ebook educates drug researchers concerning the blood-brain barrier (BBB) to allow them to impact very important advancements in a single of the main major – and so much difficult – components of drug discovery.
• Written through international specialists to supply sensible suggestions to extend mind penetration or reduce CNS side-effects
• Reviews cutting-edge in silico, in vitro, and in vivo instruments to evaluate mind penetration and complex CNS drug supply strategies
• Covers BBB body structure, medicinal chemistry layout ideas, loose drug speculation for the BBB, and shipping mechanisms together with passive diffusion, uptake/efflux transporters, and receptor-mediated processes
• Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK)
• Discusses case experiences of profitable CNS and non-CNS medicinal drugs, classes discovered and paths to the market
Read or Download Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs PDF
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